ethyl 1H-pyrazole-4-carboxylate → 1-(6-nitro-4-oxo-3,4-dihydro-quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

Ethyl pyrazole-4-carboxylate (1.83 g, 13.1 mmol) was added to a suspension of 2-chloro-6-nitro-3H-quinazolin-4-one (2.95 g, 13.1 mmol) in xylenes (52 mL). The reaction mixture was heated to 130° C. for 1 h, allowed to cool, and stirred at room temperature for 18 h. The precipitate was collected and rinsed with ether (20 mL) to yield the titled compound (4.22 g, 98%). MS (ESI/Cl): mass calcd. for C14H11N5O5, 329.1; m/z found, 330.1 [M+H]+.

Provenance & Evidence