2-Chlorophenylboronic acid → HCID 136027578, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 184, steps C-E using 1-[7-iodo-3-(2-methoxy-ethoxymethyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Intermediate from Example 184, product from step B) and 2-chlorophenylboronic acid in step C. MS (ESI): mass calcd. for C18H11ClN4O3, 366.1; m/z found, 367.0 [M+H]+. 1H NMR (500 MHz, DMSO-d6): 13.02 (br s, 1H), 12.92 (br s, 1H), 8.97 (s, 1H), 8.28 (s, 1H), 8.22 (d, J=6.6 Hz, 1H), 7.71 (s, 1H), 7.67-7.62 (m, 1H), 7.58 (d, J=7.3 Hz, 1H), 7.55-7.47 (m, 3H).

Provenance & Evidence