(3-Chlorophenyl)boronic acid → HCID 136027558, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 184, steps C-E using 1-[7-iodo-3-(2-methoxy-ethoxymethyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Intermediate from Example 184, product from step B) and 3-chlorophenylboronic acid in step C. MS (ESI): mass calcd. for C18H11ClN4O3, 366.1; m/z found, 367.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6): 13.04 (br s, 1H), 12.94 (br s, 1H), 8.97 (s, 1H), 8.28 (s, 1H), 8.21 (d, J=8.0 Hz, 1H), 8.00 (s, 1H), 7.91 (s, 1H), 7.87 (d, J=8.4 Hz, 1H), 7.82 (d, J=6.7 Hz, 1H), 7.60-7.52 (m, 2H).

Provenance & Evidence