4-Chlorophenylboronic acid → HCID 136027590, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 184, steps C-E using 1-[7-iodo-3-(2-methoxy-ethoxymethyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Intermediate from Example 184, product from step B) and 4-chlorophenylboronic acid in step C. MS (ESI): mass calcd. for C18H11ClN4O3, 366.1; m/z found, 367.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6): 12.99 (br s, 2H), 8.97 (d, J=0.6 Hz, 1H), 8.28 (s, 1H), 8.20 (d, J=8.3 Hz, 1H), 7.97 (s, 1H), 7.87 (d, J=8.5 Hz, 2H), 7.83 (dd, J=8.3, 1.7 Hz, 1H), 7.63-7.58 (m, 2H).

Provenance & Evidence