2-Methylphenyl boronic acid → HCID 136027556, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 184, steps C-E using 1-[7-iodo-3-(2-methoxy-ethoxymethyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Intermediate from Example 184, product from step B) and 2-methylphenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O3, 346.1; m/z found, 347.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 12.82 (br s, 1H), 8.92 (s, 1H), 8.10 (s, 1H), 8.08 (d, J=8.1 Hz, 1H), 7.47 (s, 1H), 7.36-7.27 (m, 5H), 2.28 (s, 3H).

Provenance & Evidence