3-Tolylboronic acid → HCID 136027633, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 184, steps C-E using 1-[7-iodo-3-(2-methoxy-ethoxymethyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Intermediate from Example 184, product from step B) and 3-methylphenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O3, 346.1; m/z found, 347.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.04 (s, 1H), 12.87 (s, 1H), 8.98 (s, 1H), 8.28 (s, 1H), 8.20 (d, J=8.2 Hz, 1H), 7.94 (s, 1H), 7.83 (d, J=8.1 Hz, 1H), 7.67 (s, 1H), 7.62 (d, J=7.0 Hz, 1H), 7.43 (t, J=7.6 Hz, 1H), 7.29 (d, J=7.5 Hz, 1H), 2.42 (s, 3H).

Provenance & Evidence