Tolylboronic acid → HCID 136027559, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 4-methylphenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O3, 346.1; m/z found, 347.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.03 (s, 1H), 12.92 (s, 1H), 8.98 (s, 1H), 8.33 (s, 1H), 8.27 (s, 1H), 8.16 (d, J=7.9 Hz, 1H), 7.77 (s, 1H), 7.69 (d, J=8.0 Hz, 2H), 7.33 (d, J=7.9 Hz, 2H), 2.37 (s, 3H).

Provenance & Evidence