2-Chlorophenylboronic acid → HCID 136027623, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 2-chlorophenylboronic acid in step C. MS (ESI): mass calcd. for C18H11ClN4O3, 366.1; m/z found, 367.0 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 12.99 (s, 2H), 8.98 (d, J=0.6 Hz, 1H), 8.27 (s, 1H), 8.13 (d, J=2.1 Hz, 1H), 7.91 (dd, J=8.4, 2.1 Hz, 1H), 7.78 (d, J=8.4 Hz, 1H), 7.64-7.61 (m, 1H), 7.55-7.52 (m, 1H), 7.47 (pd, J=7.4, 1.8 Hz, 2H).

Provenance & Evidence