3-Fluorophenylboronic acid → HCID 136027664, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 3-fluorophenylboronic acid in step C. MS (ESI): mass calcd. for C18H11FN4O3, 350.1; m/z found, 351.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.01 (br s, 2H), 8.98 (s, 1H), 8.38 (d, J=2.0 Hz, 1H), 8.29 (s, 1H), 8.22-8.20 (m, 1H), 7.80 (d, J=8.0 Hz, 1H), 7.68-7.64 (m, 2H), 7.58-7.54 (m, 1H), 7.28-7.24 (m, 1H).

Provenance & Evidence