2-Methoxyphenylboronic acid → HCID 135873929, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 2-methoxyphenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O4, 362.1; m/z found, 363.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.00 (br s, 1H), 12.84 (br s, 1H), 8.98 (s, 1H), 8.28 (s, 1H), 8.21 (d, J=1.7 Hz, 1H), 7.97 (dd, J=8.4, 2.1 Hz, 1H), 7.74 (d, J=7.0 Hz, 1H), 7.43-7.39 (m, 2H), 7.19-7.16 (m, 1H), 7.09 (td, J=7.5, 1.0 Hz, 1H), 3.81 (s, 3H).

Provenance & Evidence