(3-Methoxyphenyl)boronic acid → HCID 136027644, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 3-methoxyphenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O4, 362.1; m/z found, 363.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.01 (br s, 1H), 12.91 (br s, 1H), 8.98 (s, 1H), 8.34 (s, 1H), 8.28 (s, 1H), 8.18 (d, J=6.7 Hz, 1H), 7.78 (s, 1H), 7.44 (t, J=7.9 Hz, 1H), 7.35 (d, J=7.8 Hz, 1H), 7.29 (s, 1H), 7.00 (dd, J=8.2, 1.8 Hz, 1H), 3.86 (s, 3H).

Provenance & Evidence