(4-Methoxyphenyl)boronic acid → HCID 136027652, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 4-methoxyphenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O4, 362.1; m/z found, 363.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 12.99 (br s, 1H), 12.88 (br s, 1H), 8.97 (s, 1H), 8.28 (d, J=13.9 Hz, 2H), 8.13 (d, J=8.4 Hz, 1H), 7.78-7.72 (m, 3H), 7.09-7.06 (m, 2H), 3.82 (s, 3H).

Provenance & Evidence