2-Ethylphenylboronic Acid (contains varying amounts of Anhydride) → HCID 136027588, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 2-ethylphenylboronic acid in step C. MS (ESI): mass calcd. for C20H16N4O3, 360.1; m/z found, 361.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.01 (br s, 1H), 12.91 (br s, 1H), 8.99 (s, 1H), 8.28 (s, 1H), 7.99 (s, 1H), 7.81 (dd, J=8.2, 1.8 Hz, 1H), 7.77 (s, 1H), 7.40-7.36 (m, 2H), 7.32-7.29 (m, 1H), 7.25 (d, J=7.2 Hz, 1H), 2.59 (q, J=7.5 Hz, 2H), 1.05 (t, J=7.5 Hz, 3H).

Provenance & Evidence