2,3-Dihydro-1,4-benzodioxin-5-ylboronic acid → HCID 136027660, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 1,4-benzodioxan-5-boronic acid in step C. MS (ESI): mass calcd. for C20H14N4O5, 390.1; m/z found, 391.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.00 (s, 1H), 12.87 (s, 1H), 8.97 (s, 1H), 8.25 (s, 2H), 8.10 (d, J=7.8 Hz, 1H), 7.73 (s, 1H), 7.28-7.24 (m, 2H), 6.99 (d, J=8.4 Hz, 1H), 4.30 (s, 4H).

Provenance & Evidence