3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 136027632, compound

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Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 3-trifluoromethoxyphenylboronic acid in step C. MS (ESI): mass calcd. for C19H11F3N4O4, 416.1; m/z found, 417.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.06-12.92 (m, 2H), 8.99 (s, 1H), 8.39 (s, 1H), 8.28 (s, 1H), 8.22 (dd, J=8.4, 1.8 Hz, 1H), 7.86 (d, J=8.0 Hz, 1H), 7.79 (s, 2H), 7.66 (t, J=8.0 Hz, 1H), 7.46-7.40 (m, 1H).

Provenance & Evidence