3-(Methylsulfonyl)phenylboronic acid → HCID 136027603, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and 3-(methylsulfonyl)phenylboronic acid in step C. MS (ESI): mass calcd. for C19H14N4O5S, 410.1; m/z found, 411.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.01 (br s, 2H), 8.99 (s, 1H), 8.47 (d, J=2.1 Hz, 1H), 8.31-8.27 (m, 3H), 8.18 (d, J=8.5 Hz, 1H), 7.97 (ddd, J=7.8, 1.7, 1.0 Hz, 1H), 7.85 (d, J=7.7 Hz, 1H), 7.80 (t, J=7.8 Hz, 1H), 3.34 (s, 3H).

Provenance & Evidence