Triethylamine → HCID 86688150, compound

Participants

Reaction Steps

870 μL methanesulfonyl chloride was added to 2.5 g (1-ethyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl)-methanol and 1.85 mL triethylamine in 50 mL tetrahydrofuran. The reaction was stirred 1 h at RT and 1.4 g potassium cyanide was added and stiffing was continued for 3 h. Then 1.4 g potassium cyanide and 500 mg dibenzo-18-crone-6 was added and the reaction was stirred over night at RT. The mixture was filtered and evaporated. Dichlormethane was added to the residue and extracted with aqueous potassium carbonate solution. The organic layer was dried and evaporated. The residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 3:2) to yield 533 mg of the desired product. Rt: 1.29 min (method K), (M+H)+: 244

Provenance & Evidence