Diisopropylethylamine → 2-(1,4-Bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-1-(4-[1,3,5]triazin-2-yl-piperazin-1-yl)-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Reactant	2-(Piperazin-1-yl)-1,3,5-triazine	HCID 2760673	—
Reactant	(1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt	HCID 89620421	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	2-(1,4-Bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-1-(4-[1,3,5]triazin-2-yl-piperazin-1-yl)-ethanone	HCID 71599772	64.2%

Reaction Steps

22 mg 1-(1,3,5-triazin-2-yl)-piperazine was added to 40 mg (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt, 45 mg TBTU, 0.03 mL DIPEA in 0.75 mL DMF. The reaction was stirred overnight at RT. 5 mL water was added to the reaction and the mixture was stirred 1 h. The precipitate was filtered and dried to give 37 mg desired product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08937176B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-0bd3b8d641e5473daa1a3b759765c740
Source note	uspto-grants-2015_01