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Cis-3-azido-6-benzhydryl-tetrahydropyran → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cis-3-azido-6-benzhydryl-tetrahydropyran | HCID 11630718 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine | HCID 11565229 | 78% |
反応手順
Cis-5-azido-2-diphenylmethyl-tetrahydropyran 14 (0.3 g, 1.02 mmol) in methanol (25 ml) was hydrogenated under the catalyst of 10% Pd—C (0.03 g, 10% wt) for 4 hr (Procedure C) to give cis-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.21 g, 78%) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08937189B2 |
| 出典データセット | uspto-grants-2015_01 |
| ORD ID | ord-4e614def2bf44fc383d77ceaaa12e79d |
| 出典メモ | uspto-grants-2015_01 |