Sodium Methoxide → 2-[(2,5-Dimethylphenoxy)methyl]benzaldehyde

HRID 1429069Notes

Reaction equation

HRID 1429069 reaction equation
[CH3:1][C:2]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:3]=1[O:4][CH2:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[CH:8](Cl)Cl.C[O-:21].[Na+]>>[CH3:1][C:2]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:3]=1[O:4][CH2:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[CH:8]=[O:21]

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 67069149HCID 67069149, compound

Product 1

HCID 446094212-[(2,5-Dimethylphenoxy)methyl]benzaldehyde

Procedure

As a process for producing 2-(aryloxymethyl)benzaldehyde, for example, the following method is described in JP 2009-215286 A (Example 5). In the method, 2-(2,5-dimethylphenoxymethyl)benzaldehyde is obtained by reacting 2-(2,5-dimethylphenoxymethyl)benzal chloride and sodium methoxide, and then a resulting acetal compound is extracted with xylene. Then, an organic layer obtained after liquid separation is mixed with an aqueous sulfuric acid solution to hydrolyze the acetal compound to obtain 2-(2,5-dimethylphenoxymethyl)benzaldehyde.

Workup

  1. extractiona resulting acetal compound is extracted with xylene
  2. customThen, an organic layer obtained
  3. customafter liquid separation
  4. additionis mixed with an aqueous sulfuric acid solution

Sources & evidence

ORD record
ord-7109e00efeb04009b8e167010f65129a
Source dataset
uspto-grants-2015_01
Patent number
US08937200B2

Reaction notes

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