HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68590569, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68590160 | HCID 68590160 | — |
| Reactant | HCID 86641378 | HCID 86641378 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68590569 | HCID 68590569 | 78% |
Reaction Steps
Compound 3g (583 mg, 1.227 mmol) was dissolved in 15 ml dry DMF. DIEA (0.96 ml, 5.522 mmol), N-methylhexeneamine×HCl (270 mg, 1.779 mmol) and HATU (676 mg, 1.779 mmol) were added at 0° C., and the reaction mixture was stirred at RT over night. The DMF was evaporated and the residue was dissolved in EtOAc and washed with saturated NaHCO3(aq), H2O and brine. The organic layer was dried (MgSO4), filtered and evaporated. Purification by column chromatography (heptane/EtOAc) gave the pure title compound (550 mg, 78%), MS (M+H)+573.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-1c4e35f584dd4f4ab0717d05c6608199 |
| Source note | uspto-grants-2015_01 |