HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68590569, compound → HCID 68589805, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68590569 | HCID 68590569 | — |
| Catalyst | (1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)ruthenium | HCID 11763533 | — |
| Product | HCID 68589805 | HCID 68589805 | 74.1% |
Reaction Steps
Compound 3h (500 mg, 0.87 mmol) and Hoveyda-Grubbs catalyst, 2nd generation (50 mg) were dissolved in degassed and dry DCE (500 ml). The mixture was heated to reflux over night under N2-atmosphere. The material was mixed with silica, the solvent was evaporated and the residue was purified by column chromatography, EtOAc/Heptane 30:70→50:50 which gave the title compound (350 mg, 74%), MS (M+H)+543.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-b0538ce6bc00418bb7b210203003b966 |
| Source note | uspto-grants-2015_01 |