Citric Acid → HCID 75277250, compound

Participants

Role	Name	HCID	Charge
Reactant	Citric Acid	HCID 311	—
Reactant	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
Reactant	1,8-Diazabicyclo(5.4.0)undec-7-ene	HCID 81184	—
Reactant	Cyclopropanesulfonamide	HCID 15765418	—
Reactant	HCID 68591633	HCID 68591633	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 75277250	HCID 75277250	—

Reaction Steps

Compound 3j (120 mg, 0.233 mmol) was dissolved in DCM (10 ml). EDAC (54 mg, 0.28 mmol) was added and the reaction mixture was stirred at RT for 2.5 h. Cyclo-propanesulfonic acid amide (31 mg, 0.256 mmol) and DBU (73 μl, 0.489 mmol) were added and the reaction mixture was stirred at RT over night. 5% Citric acid was added and the organic layer was washed with brine, dried, filtered and evaporated. Purifica-tion by preparative HPLC yielded the pure title compound of (65 mg, 45%), MS (M+H)+618.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08937080B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-f799d9a0ac40417db0c1c8c2dc364844
Source note	uspto-grants-2015_01