HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 72253702, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-Methylcyclopropane-1-sulfonamide | HCID 21889814 | — |
| Reactant | HCID 68591016 | HCID 68591016 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 72253702 | HCID 72253702 | — |
Reaction Steps
Compound 2d (130 mg, 0.198 mmol) was dissolved in DCM (10 ml). EDAC (46 mg, 0.238 mmol) was added and the reaction mixture was stirred at RT for 2.5 h. Methyl cyclopropanesulfonic amide (30 mg, 0.3218 mmol) and DBU (63 μl, 0.416 mmol) were added and the mixture was stirred at RT over night. 5% Citric acid was added and the organic layer was washed with brine, dried, filtered and evaporated. The material was used directly in the following step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-37e580e4d9e045329c72608962a531c4 |
| Source note | uspto-grants-2015_01 |