HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 75277251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 72253702 | HCID 72253702 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 75277251 | HCID 75277251 | 16% |
Reaction Steps
Compound 4a was dissolved in a 1:2 mixture of TFA:DCM (12 ml) and stirred at RT for 1 h. NaHCO3 was added and the organic layer was dried, filtered and evaporated. The afforded residue was purified by preparative HPLC which gave the pure title compound (36 mg, 16% over two steps), MS (M+H)+639.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-0de268cc01594eafabdb038723b7b498 |
| Source note | uspto-grants-2015_01 |