HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 68590619, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68590606 | HCID 68590606 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68590619 | HCID 68590619 | 78% |
Reaction Steps
Compound 6e (410 mg, 0.60 mmol) was dissolved in a 2:1:1 mixture of THF:MeOH:H2O (144 ml). LiOH (1 M, 6 ml) was added and the reaction mixture was stirred at RT over night. 5% Citric acid was added followed by DCM. The organic layer was dried (MgSO4), filtered and evaporated which gave the title compound (305 mg, 78%), MS (M+H)+656.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-4fce611200514de9bb12df4719815ef1 |
| Source note | uspto-grants-2015_01 |