HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 75277253, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 72253699 | HCID 72253699 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 75277253 | HCID 75277253 | 8% |
Reaction Steps
Compound 6g was dissolved in a 1:2 mixture of TFA:DCM (24 ml) and stirred at RT for 1 h. NaHCO3 was added and the organic layer was separated of, dried, filtered and evaporated. The residue was purified by preparative HPLC which gave the pure title compound (19 mg, 8% over two steps), MS (M+H)+639.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-7ace2e1133564ba4935b981b67067850 |
| Source note | uspto-grants-2015_01 |