HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 68592522, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68592566 | HCID 68592566 | — |
| Reactant | HCID 86641379 | HCID 86641379 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68592522 | HCID 68592522 | — |
Reaction Steps
Compound 7b (1.32 g, 2.67 mmol) was dissolved in 30 ml dry DMF. DIEA (2.1 ml, 12.0 mmol), N-methylhexeneamine HCl (440 mg, 3.9 mmol) and HATU (1.48 g, 3.9 mmol) were added at 0° C., and the reaction mixture was stirred at RT over night. The DMF was evaporated and the residue was dissolved in EtOAc, washed with sat. NaHCO3(aq), H2O and brine. The organic layer was dried (MgSO4), filtered and evaporated, followed by column chromatography (Heptane/EtOAc), giving the title compound. (1.1 g, 70%), MS (M+H)+591.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-088e24e0cb294c4bb9dbb6beadb433d3 |
| Source note | uspto-grants-2015_01 |