Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68589639 | HCID 68589639 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68591104 | HCID 68591104 | 100% |
Reaction Steps
Compound 7d (362 mg, 0.644 mmol) was dissolved in a 2:1:1 mixture of THF:MeOH:H2O (100 ml). LiOH (1 M, 6.5 ml) was added and the reaction mixture was stirred at 60° C. for 72 h. The reaction mixture was acidified by addition of 5% citric acid whereafter DCM was added. The organic layer was separated, dried (MgSO4), filtered and evaporated which gave the title compound (344 mg, 100%), MS (M+H)+535.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08937080B2 |
|---|
| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-5e2f74318cf3456792b563324e0042e8 |
|---|
| Source note | uspto-grants-2015_01 |
|---|
