HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 74341329, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-Methylcyclopropane-1-sulfonamide | HCID 21889814 | — |
| Reactant | HCID 68591104 | HCID 68591104 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 74341329 | HCID 74341329 | 90.3% |
Reaction Steps
Compound 7e (100 mg, 0.187 mmol) was dissolved in DCM (5 ml), and EDAC (43 mg, 0.224 mmol) was added. The reaction mixture was stirred at RT for 1 h. Methylcyclopropanesulfonic amide (28 mg, 0.206 mmol) and DBU (59 μl, 0.393 mmol) were added and the reaction mixture was stirred at RT over night. Citric acid was added and the organic layer was separated, washed with brine, dried, filtered and evaporated. Purification of the residue by preparative HPLC provided the pure title compound (110 mg, 90%), MS (M+H)+652.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-7f5403e50e774b088f02071accffafad |
| Source note | uspto-grants-2015_01 |