Diisopropylethylamine → HCID 68590970, compound

Participants

Reaction Steps

To a ice cooled solution of the crude acid 13b (1.2 g, 1.81 mmol), N-methylhexeneamine hydrochloride (0.404 g, 2.7 mmol) and DIEA (1.2 g, 9.1 mmol) was added HATU (1.02 g, 2.7 mmol) and the mixture was stirred for twenty minutes on an ice bath and two hours at room temperature. A saturated solution of sodium hydrogen carbonate was added and the mixture was extracted three times with ethyl acetate. The combined organic phases were washed with saturated sodium hydrogen carbonate and brine and dried with sodium sulphate, filtered and evaporated under reduced pressure. The product was isolated by silica gel chromatography with hexane ethyl acetate, (0.8 g, 74%), (M+H)+591.

Provenance & Evidence