Citric Acid → HCID 68591013, compound

Participants

Reaction Steps

To a solution of compound 13d (470 mg, 0.83 mmol) in a mixture of THF methanol 1:1 (30 ml) was added 1 M LiOH solution (10 ml) and the mixture was stirred for four days at room temperature. A 5% solution of citric acid was added and the mixture was extracted three times with ethyl acetate. The organic phase was dried with sodium sulphate and evaporated on silica gel. The product was isolated by silica gel chromatography eluted with DCM methanol, (400 mg, 88%), (M+H)+535.

Provenance & Evidence