HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 131732365, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Cyclopropanesulfonamide | HCID 15765418 | — |
| Reactant | HCID 68591013 | HCID 68591013 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131732365 | HCID 131732365 | 56% |
Reaction Steps
A solution of the acid 13e (150 mg, 0.28 mmol) and EDAC (65 mg, 0.34 mmol) in dry DCM (3 ml) was stirred overnight. Cyclopropane sulphonamide (72.7 mg, 0.6 mmol) and DBU (120 mg, 0.8 mmol) was added and the mixture was stirred overnight at room temperature. 5% Citric acid was added and the mixture was extracted with ethyl acetate. The organic phase was washed two times with 5% citric acid and water, dried with sodium sulphate and evaporated under reduced pressure. Purification by HPLC gave the title compound, (100 mg, 56%), (M+H)+638
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-8630a4e1261940b9b88146b68cd10c03 |
| Source note | uspto-grants-2015_01 |