HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 75277259, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Cyclopropanesulfonamide | HCID 15765418 | — |
| Reactant | HCID 68592856 | HCID 68592856 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 75277259 | HCID 75277259 | 45% |
Reaction Steps
The acid 16f (195 mg, 0.34 mmol) was reacted with cyclopropane sulfonamide (53 mg, 0.44 mmol), EDAC (85 mg, 0.44 mmol) and DBU (137 mg, 0.9 mmol) in dry DCM (3 ml) according to the procedure described in Example 13 step f. Purification by column chromatography on silica gel eluted with diethyl ether-ethyl acetate gave the title compound, (100 mg, 45%), (M+H)+668.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-b4dbc961cc9440a2bc03fe0c4891941d |
| Source note | uspto-grants-2015_01 |