HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 68590387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68592125 | HCID 68592125 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | HCID 68590387 | HCID 68590387 | 99.1% |
Reaction Steps
A solution of the ethyl ester 18f (0.33 g, 0.64 mmol) in THF/MeOH 1:1 (20 ml) was treated with a 1M solution of LiOH (10 ml) as described in Example 13 step d. Purification by column chromatography on silica gel eluted with DCM-MeOH gave the title compound, (0.31 g, 99%), (M+H)+489.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-28cebc5d8fa249e0b0e154c9bc01435d |
| Source note | uspto-grants-2015_01 |