反应详情

Methyl iodide (32.64 g, 220 mmol) was added dropwise to a suspension of thiobarbituric acid (29 g, 200 mmol) in EtOH (300 ml) and 2M NaOH solution in water (110 ml) at room temperature. The mixture was stirred at room temperature overnight and then stirred for two hours at 60° C. The ethanol was removed, water was added and the mixture was allowed to stay for 2 hours on an ice bath. The solid title compound was filtered of, washed with ice cold water and dried (30 g, 95%).

1. stirringstirred for two hours at 60° C
2. customThe ethanol was removed
3. additionwater was added
4. waitto stay for 2 hours on an ice bath
5. filtrationThe solid title compound was filtered of,
6. washwashed with ice cold water
7. customdried (30 g, 95%)