Cyclopropanesulfonamide → HCID 131732366, compound

HRID 1429194Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH:10]2[CH2:27][CH:26]3[CH:12]([C:13](=[O:33])[N:14]([CH3:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]=[CH:20][CH:21]4[C:23]([C:29](O)=[O:30])([NH:24][C:25]3=[O:28])[CH2:22]4)[CH2:11]2)[CH:6]=[C:5]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=2)[N:4]=1.[CH:42]1([S:45]([NH2:48])(=[O:47])=[O:46])[CH2:44][CH2:43]1>>[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH:10]2[CH2:27][CH:26]3[CH:12]([C:13](=[O:33])[N:14]([CH3:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]=[CH:20][CH:21]4[C:23]([C:29]([NH:48][S:45]([CH:42]5[CH2:44][CH2:43]5)(=[O:47])=[O:46])=[O:30])([NH:24][C:25]3=[O:28])[CH2:22]4)[CH2:11]2)[CH:6]=[C:5]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=2)[N:4]=1

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 68590894HCID 68590894, compound

Product 1

HCID 131732366HCID 131732366, compoundYield 63.4%

Procedure

The acid 25 (150 mg, 0.26 mmol) was reacted with cyclopropane sulphonamide (64 mg, 0.53 mmol) according to the procedure described in Example 16 step g, which gave the title compound (110 mg, 62%), MS [M+1] 668.

Sources & evidence

ORD record: ord-24ee2ce3b22243bea81a14558e7d7a7d
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08937080B2

Reaction notes

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