1-Methylcyclopropane-1-sulfonamide → HCID 131732367, compound

HRID 1429195Notes

Reaction equation

HRID 1429195 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH:10]2[CH2:27][CH:26]3[CH:12]([C:13](=[O:33])[N:14]([CH3:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]=[CH:20][CH:21]4[C:23]([C:29](O)=[O:30])([NH:24][C:25]3=[O:28])[CH2:22]4)[CH2:11]2)[CH:6]=[C:5]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=2)[N:4]=1.[CH3:42][C:43]1([S:46]([NH2:49])(=[O:48])=[O:47])[CH2:45][CH2:44]1>>[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH:10]2[CH2:27][CH:26]3[CH:12]([C:13](=[O:33])[N:14]([CH3:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]=[CH:20][CH:21]4[C:23]([C:29]([NH:49][S:46]([C:43]5([CH3:42])[CH2:45][CH2:44]5)(=[O:48])=[O:47])=[O:30])([NH:24][C:25]3=[O:28])[CH2:22]4)[CH2:11]2)[CH:6]=[C:5]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=2)[N:4]=1

Participants

3

Reactant 2

HCID 218898141-Methylcyclopropane-1-sulfonamideHCID 68590894HCID 68590894, compound

Product 1

HCID 131732367HCID 131732367, compoundYield 50.8%

Procedure

The acid 25 (150 mg, 0.26 mmol) was reacted with methylcyclopropane sulphonamide (72 mg, 0.53 mmol) according to the procedure described in Example 16 step g, which gave the title compound (90 mg, 50%), MS [M+1] 682.

Sources & evidence

ORD record
ord-dd0ef5ede2ea445e89e2c792a734f1b7
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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