反应详情

1-(4-tert-Butylphenyl)-2,5-bis(4-chloro-3-nitrophenyl)pyrrolidine (4.41 g, 8.57 mmol) was combined, neat, with p-methoxy benzylamine (8.93 mL, 68.6 mmol) and heated at 145° C. for 1 hour. The mixture was diluted with dichloromethane and filtered. The filtrate was washed with 0.5 M HCl, NaHCO3 solution, and then brine. The organic phase was concentrated and purified by chromatography on silica gel with an 80 g column, eluting with 0-50% ethyl acetate/hexanes to give 4.13 g (67%) of an orange foamy solid.

1. filtrationfiltered
2. washThe filtrate was washed with 0.5 M HCl, NaHCO3 solution
3. concentrationThe organic phase was concentrated
4. custompurified by chromatography on silica gel with an 80 g column
5. washeluting with 0-50% ethyl acetate/hexanes