Citric Acid → HCID 69915440, compound

Participants

Reaction Steps

Citric acid (0.51 g) was added to a solution of ethyl 4-(5-chloro-2-nitrophenyl)-4-(trimethylsilyloxy)butanoate (4.76 g) in ethanol (25 mL) and water (5 mL) and stirred at room temperature for 1.5 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The ethyl acetate layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. Subsequently, the solvent was distilled off and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=20:1→10:1) to obtain 3.8 g of ethyl 4-(5-chloro-2-nitrophenyl)-4-hydroxybutanoate.

Provenance & Evidence