2-Methoxybenzenesulfonyl Chloride → HCID 67417832, compound

Participants

Reaction Steps

To a solution of compound 2b (800 mg, 2.8 mmol) in pyridine (20 mL) was added 2-methoxybenzene-1-sulfonyl chloride (942 mg, 4.5 mmol) at 10° C. The mixture was stirred at rt overnight and then concentrated in vacuo. The residue was dissolved in DCM (20 mL), washed with water (20 mL) and brine (20 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel flash chromatography (PE:EA=2:1) to give compound 2c as a white solid (1.13 g, 83% yield).

Provenance & Evidence