Hydrochloric Acid → HCID 67418262, compound

Participants

Reaction Steps

The mixture of compound 2e (100 mg, 0.17 mmol) and hydrazine monohydrate 98% (85 mg, 1.7 mmol) in ethanol (5 mL) was heated to reflux for 2 hr. The reaction mixture was cooled down to rt and acidified to pH=3 with 1N aqueous HCl. The precipitate was removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by prep-HPLC to give compound 2f as a white solid (30 mg, 39% yield).

Provenance & Evidence