HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1429365Generated: October 31, 2026
Trifluoroacetic acid → 1((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt
https://huagongshe.com/reaction/1429365
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl(1-((2-(bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-yl)carbamate | HCID 123844053 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt | HCID 67382252 | 95% |
Reaction Steps
To a solution of compound 3i (2.2 g, 4.3 mmol) in DCM (20 mL) was added slowly TFA (2 mL) at 0° C. The mixture was stirred at 0° C. for 2 hr. LCMS analysis indicated the total consumption of compound 3i. The solvent was removed in vacuum to give 3k as a white solid (1.68 g, 95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08940722B2 |
|---|
| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-2acb14afbf5a4ad8995a72ace2448417 |
|---|
| Source note | uspto-grants-2015_01 |
|---|
