HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 68233575, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68233578 | HCID 68233578 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68233575 | HCID 68233575 | 46.4% |
Reaction Steps
To a solution of compound 14d (394 mg, 1.4 mmol) and HATU (639 mg, 1.68 mmol) in DMF (20 mL) at rt was added DIPEA (1 mL). The reaction mixture is stirred for 16 h, quenched with H2O and extracted with EA (100 mL). The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by CC on silica gel, eluting with PE/EA=4:1 to give compound 14e (171 mg, 46% yield) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940722B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-c5779f7f1a4246b29439cad9235b82aa |
| Source note | uspto-grants-2015_01 |