Aluminium lithium hydride → HCID 68233579, compound

Participants

Reaction Steps

To a solution of compound 14e (171 mg, 0.65 mmol) in THF (6 mL) at 0° C. was added LiAlH4 (247 mg, 6.5 mmol). The reaction mixture was heated under reflux for 16 h, cooled to rt, quenched with H2O and filtered. The mixture was extracted with CHCl3 (10 mL), washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was washed with hexanes to give compound 14f (129 mg), which was used in the next step without further purification.

Provenance & Evidence