Hydrochloric Acid → HCID 178527292, compound

Participants

Reaction Conditions

Reaction Steps

To the mixture of sodium azide (48 mg, 0.75 mmol) and ammonium chloride (40 mg, 0.75 mmol) in dry DMF (5 mL) was added compound 24 (100 mg, 0.25 mmol) under a nitrogen atmosphere. The mixture was stirred at 125° C. for 48 hr. The cooled reaction was poured into ice water and acidified to pH=1 with 1N HCl. The mixture was concentrated in vacuo and purified by Prep-HPLC to obtain compound 25 (30 mg, 27% yield). LCMS (m/z): 437.2 (MH+).

Provenance & Evidence