Dimethylamine → HCID 71269506, compound

Participants

Reaction Steps

A solution of compound 21a (100 mg, 0.24 mmol) in SOCl2 (3 mL) was stirred at rt for 1 h and concentrated. Dimethylamine (32.8 mg, 0.4 mmol) and triethylamine (81 mg, 0.81 mmol) in DCM (5 mL) were added to the above residue. The mixture was stirred at rt for 1 h. The mixture was taken up in H2O (10 mL) and extracted with DCM (30 mL). The organic layers were dried over Na2SO4 and concentrated. The crude product was purified Prep-TLC to give the pure compound 26 (40 mg, 38% yield). LCMS (m/z): 440.1 (MH+).

Provenance & Evidence