Triethylamine → HCID 71269526, compound

Participants

Reaction Steps

A mixture of compound 21a (412 mg, 1 mmol) and SOCl2 (3 mL) was stirred at rt for 1 h and concentrated. 2-Amino-1-phenylethanone (342 mg, 2 mmol) and triethylamine (303 mg, 3 mmol) in DCM (5 mL) were added to the above residue. The mixture was stirred at rt for 1 h. The reaction was taken up in H2O (10 mL) and extracted with DCM (30 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated. The crude product was purified by CC to give compound 28a (400 mg, 75% yield).

Provenance & Evidence