HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-2-(N-(5-Amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-2-(N-(5-((tert-Butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid | HCID 71269086 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-2-(N-(5-Amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid | HCID 71269357 | — |
Reaction Steps
To a solution of compound 31k (2.8 g, 5 mmol) in DCM (100 mL) was added TFA (20 mL). After the reaction was over, the solvents were removed by reduced pressure to give a white solid. The product was used in the next reaction step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940722B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-3b8f6490e6204f158375e21699aaa1c0 |
| Source note | uspto-grants-2015_01 |