Citric Acid → HCID 67382508, compound

Participants

Role	Name	HCID	Charge
Reactant	Citric Acid	HCID 311	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Bis(2-oxo-3-oxazolidinyl)phosphinic chloride	HCID 152842	—
Reactant	(S)-2-(N-(5-Amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid	HCID 71269357	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 67382508	HCID 67382508	88%

Reaction Steps

To a solution of compound 31l (2.3 g, 5.0 mmol) in DCM (50 mL) was added DIPEA (2.6 g, 20 mmol) and BOP-Cl (1.5 g, 6.0 mmol). The reaction mixture was stirred at rt for 5 h under nitrogen, then 50 mL DCM and 10% citric acid were added to the mixture. The organic layer was separated, washed with brine and dried over anhydrous Na2SO4. After filtration, the filtrate was evaporated and the residue was purified by CC (hexane/EA=3:1) to give compound 31m (1.9 g, 88% yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08940722B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-ff245f783b62440cab498cdd3e45e389
Source note	uspto-grants-2015_01